Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits

Acta Cirurgica Brasileira

Hua Tang¹  Donggang Zhao¹  Shaojun Chen¹  Ming Fang¹  Feifan Wang¹  Ying Cui¹  Na Tang¹  Qianxue Chen¹ 

关键词: Vasospasm;    Intracranial;    Subarachnoid Hemorrhage;    Sphingosine;    Rabbits;   

DOI  :  10.1590/S0102-865020150100000001

来源: SciELO

【 摘 要 】

PURPOSE: To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH).METHODS: The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9.RESULTS:The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery cross-sectional area changes at day 3, 5, 7, 9.CONCLUSION:Sphingosine-1-phosphate expression in the cerebral arterial may be a new indicator in the development of cerebral vasospasm after subarachnoid hemorrhage and provide a new therapeutic method for SAH.

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