Acta Cirurgica Brasileira | |
Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits | |
Hua Tang1  Donggang Zhao1  Shaojun Chen1  Ming Fang1  Feifan Wang1  Ying Cui1  Na Tang1  Qianxue Chen1  | |
关键词: Vasospasm; Intracranial; Subarachnoid Hemorrhage; Sphingosine; Rabbits; | |
DOI : 10.1590/S0102-865020150100000001 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH).METHODS: The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9.RESULTS:The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery cross-sectional area changes at day 3, 5, 7, 9.CONCLUSION:Sphingosine-1-phosphate expression in the cerebral arterial may be a new indicator in the development of cerebral vasospasm after subarachnoid hemorrhage and provide a new therapeutic method for SAH.
【 授权许可】
CC BY
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