Selenium protects cerebral cells by cisplatin induced neurotoxicity

Acta Cirurgica Brasileira

Ergun Karavelioglu¹  Mehmet Gazi Boyaci¹  Nejdet Simsek¹  Mehmet Akif Sonmez¹  Rabia Koc¹  Mustafa Karademir¹  Mustafa Guven¹  Olcay Eser¹ 

关键词: Cisplatin;    Selenium;    Neurotoxicity;    Rats;   

DOI  :  10.1590/S0102-865020150060000004

来源: SciELO

【 摘 要 】

PURPOSE:To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium.METHODS:Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered to CS and CSE groups for three days. Furthermore, CSE group received 3mg/kg/day (twice-a-day as 1.5 mg/kg) selenium via oral gavage five days before cisplatin injection and continued for 11 consecutive days. The same volumes of saline were administered to C group intraperitoneally and orally at same time.RESULTS:Heterochromatic and vacuolated neurons and dilated capillary vessels in the brain were observed in the histochemical examinations of cisplatin treated group. Rats that were given a dose of 3mg/kg/day selenium decreased the cisplatin induced histopathological changes in the brain, indicating a protective effect. In addition, cytoplasmic staining of the cell for bcl-2, both cytoplasmic and nuclear staining for bax were determined to be positive in the all groups. Bax positive cells were increased in the CS group compared to C group, in contrast to decreased bcl-2 positivity.CONCLUSION:Selenium limited apototic activity and histological changes due to the cisplatin related central neurotoxicity.

【 授权许可】

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