Deleterious effects of prepubertal corticosterone treatment on rat prostate

Acta Cirurgica Brasileira

Flávia Cristina Morone Pinto¹  Dílson Silva¹  Pamella Campos Silva¹  Luiza Morone Pereira¹  Arlene Regina Morone¹  Waldemar Silva Costa¹  Célia Martins Cortez¹  Francisco José Barcellos Sampaio¹ 

关键词: Corticosterone;    Glucocorticoids;    Prostate;    Anatomy & Histology;    Rats;   

DOI  :  10.1590/S0102-865020150060000002

来源: SciELO

【 摘 要 】

PURPOSE:To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase.METHODS:Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups: 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis.RESULTS:Acini distribution in the group treated with CORT differed significantly (p<0.0001) from the control. The control group's epithelial average height (10.01±0.24 microns) was statistically significant (p<0.0001) from rats treated with CORT (19.27±0.73microns). The collagen distribution was lower in the treated group (2.79%) when compared to control (3.97%). The radioactivity percentage in the groups marked with 99mTc-P (%Ati/g) did not demonstrate a statistically significant difference (p=0.285897).CONCLUSION:Chronic administration of corticosterone in prepubertal rats causes changes in their acinar structure and their ventral prostate stroma, indicating possible deleterious effects of this hormone.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License