Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

Acta Cirurgica Brasileira

José Pedro Calistro Neto¹  Rômulo Da Costa Torres¹  Giovanna Maria Gonçalves¹  Leopoldo Muniz Da Silva¹  Maria Aparecida Custódio Domingues¹  Norma Sueli Pinheiro Módolo¹  Guilherme Antonio Moreira De Barros¹ 

关键词: Parecoxib;    Ischemia;    Reperfusion;    Kidney;    Rats;   

DOI  :  10.1590/S0102-865020150040000006

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.

【 授权许可】

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