Acta Cirurgica Brasileira | |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats | |
José Pedro Calistro Neto1  Rômulo Da Costa Torres1  Giovanna Maria Gonçalves1  Leopoldo Muniz Da Silva1  Maria Aparecida Custódio Domingues1  Norma Sueli Pinheiro Módolo1  Guilherme Antonio Moreira De Barros1  | |
关键词: Parecoxib; Ischemia; Reperfusion; Kidney; Rats; | |
DOI : 10.1590/S0102-865020150040000006 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:Parecoxib resulted in renal protection in this experimental model.
【 授权许可】
CC BY
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