Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

Acta Cirurgica Brasileira

Thamyris Candida¹  Jerônimo Pereira De França¹  Alba Lucilvânia Fonseca Chaves¹  Fernanda Andrade Rodrigues Lopes¹  Silvana Gaiba¹  Celio Kersul Do Sacramento¹  Lydia Masako Ferreira¹  Lucimar Pereira De França¹ 

关键词: Morinda citrifolia L.;    Morinda;    Drug Screening Assays Antitumor;    Anti-Infective Agents;    Antimicrobial;   

DOI  :  10.1590/S0102-86502014001400003

来源: SciELO

【 摘 要 】

PURPOSE:To evaluate the antitumor and antimicrobial activity of ethanolic extract of Morinda citrifolia L. fruit cultivated in southeastern Brazil.METHODS:Preparation ethanolic extract of the fruit of Morinda citrifoliaL. Culture of melanoma cells B16-F10 for treatment with ethanolic extract of Morinda citrifolia L. fruit to determine cell viability by MTT and determination temporal effect of ethanolic extract fruit on the cell growth B16-F10 for 8 days. Evaluation of antimicrobial activity of ethanolic extract fruit against Staphylococcus aureusand Escherichia coli by determination of Minimum Inhibitory Concentration (MIC).RESULTS:The ethanolic extract of Morinda citrifolia L. fruit (10mg/mL) decreased cellular activity and inhibited 45% the rate of cell proliferation of B16-F10 melanoma treated during period studied. The ethanolic extract of Morinda citrifolia L. fruit demonstrated antimicrobial activity inhibiting the growth of both microorganisms studied. Staphylococcus aureuswas less resistant to ethanolic extract of Morinda citrifolia L. fruit than Escherichia coli, 1 mg/mL and 10 mg/mL, respectively.CONCLUSION: What these results indicate that the ethanolic extract of the fruit of Morinda citrifolia L. showed antitumor activity with inhibition of viability and growth of B16-F10 cells and also showed antibacterial activity as induced inhibition of growth of Staphylococcus aureusand Escherichia coli.

【 授权许可】

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