Effects of catecholamines on volemic replacement with saline solution and the impact on heart rate variability in rabbits subjected to hemorrhage. A study by spectral analysis

Acta Cirurgica Brasileira

José Mariano Soares De Moraes¹  Matheus Fachini Vane¹  Denise De Fátima Rodrigues¹  Cristiano Teixeira Mostarda¹  Thiago Soares Mendes Moreira De Moraes¹  Lucas Fachini Vane¹  Eliana Marisa Ganem¹  Ismar Lima Cavalcanti¹  Norma Sueli Pinheiro Módolo¹  Luiz Antonio Vane¹ 

关键词: Catecholamines;    Adrenergic alpha-Agonists;    adrenergic beta-Agonists;    Blood Volume;    Hemorrhage;    Autonomic Nervous System;    Rabbits;   

DOI  :  10.1590/S0102-86502014001800002

来源: SciELO

【 摘 要 】

PURPOSE: To verify the effects of different catecholamines on volemic expansion and on the autonomic nervous system in rabbits that were subjected to hemorrhage.METHODS: Twenty four rabbits subjected to hemorrhage (with a 25% loss of blood volume) and were randomly divided into four experimental groups: 1) HEMO Group underwent replacement with their own blood in an equal volume; 2) SS Group underwent replacement with saline solution (SS) in a volume that corresponded to three times the removed blood volume; 3) ISP Group underwent replacement with SS and isoprenaline; 4) FNL Group underwent replacement with SS and phenylephrine. Spectral Analysis of the heart rate and heart rate variability were performed from the recorded data. Hematocrit was measured throughout the experiment.RESULTS:Replacement with SS and an α- or β-agonist did not produce differences in the intravascular retention compared to replacement with SS alone. An analysis of HRV showed that the FNL group maintained the LF/HF ratio better than ISP and SS.CONCLUSIONS: No difference in vascular retention when α- or β- agonists were added to SS during post-hemorrhagic recovery. The animals in the FNL group maintained the integrity of the autonomic response within normal physiological standards during hemorrhagic stress.

【 授权许可】

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