Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis

Acta Cirurgica Brasileira

José Roosevelt Cavalcante¹  João Paulo Aguiar Sampaio¹  João Tarcísio Alves Maia Filho¹  Renato Braga Vieira¹  José Eleutério Júnior¹  Roberto César Pereira Lima Júnior¹  Ronaldo Albuquerque Ribeiro¹  Paulo Roberto Carvalho Almeida¹ 

关键词: Cadherins;    Immunohistochemistry;    Cervical Intraepithelial Neoplasia;    Neoplasms squamous cell;    Uterine Cervical Neoplasms;   

DOI  :  10.1590/S0102-8650201400160007

来源: SciELO

【 摘 要 】

PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License