Modulatory activity of brazilian red propolis on chemically induced dermal carcinogenesis

Acta Cirurgica Brasileira

Kariny Souza Pinheiro¹  Danielle Rodrigues Ribeiro¹  Angela Valéria Farias Alves¹  Rose Nely Pereira-filho¹  Clauberto Rodrigues De Oliveira¹  Sônia Oliveira Lima¹  Francisco Prado Reis¹  Juliana Cordeiro Cardoso¹  Ricardo Luiz Cavalcanti De Albuquerque-júnior¹ 

关键词: DMBA;    Squamous Cell Cancer;    Skin Cancer;    Rodents;    Propolis;   

DOI  :  10.1590/S0102-86502014000200007

来源: SciELO

【 摘 要 】

PURPOSE:To evaluate modulatory effects of a hydroalcoholic extract of Brazilian red propolis (HERP) on dermal carcinogenesis using a murine model.METHODS: The HERP was used at concentrations of 10, 50 and 100 mg/kg (PROP10, PROP50 and PROP100, respectively) to modulate dermal carcinogenesis induced by the application of 9,10-dimetil-1,2-benzatraceno (DMBA) on the backs of animals.RESULTS:The chemical compounds identified in HERP included propyl gallate, catechin, epicatechin and formononetin. PROP100 treatment resulted in significantly decreased tumor multiplicity throughout the five weeks of tumor promotion (p<0.05), and this concentration also resulted in the highest frequency of verrucous tumors (p<0.05). All of the tumors that developed in DMBA-treated animals were regarded as squamous cell carcinomas and were either diagnosed as non-invasive verrucous carcinomas or invasive squamous cell carcinomas (SCCs). The average score for malignancy was significantly lower in the PROP100-treated group than the non-treated group (p<0.05), but there was no difference between the other groups (p>0.05).CONCLUSION: The oral administration of hydroalcoholic extract of Brazilian red propolis at a dose of 100 mg/kg had a significant modulatory effect on the formation, differentiation and progression of chemically induced squamous cell carcinoma in a murine experimental model.

【 授权许可】

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