Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs

Acta Cirurgica Brasileira

Dincer Yilmaz¹  Necdet Dogan¹  Aydin Ozkan¹  Metin Sencimen¹  Baris Eren Ora¹  Ibrahim Mutlu¹ 

关键词: Calcium Phosphates;    Bone Regeneration;    Tibia;    Blood Platelets;    Swine;   

DOI  :  10.1590/S0102-86502014000100009

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects.METHODS: Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically.RESULTS: Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone.CONCLUSION: The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.

【 授权许可】

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