Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice

Acta Cirurgica Brasileira

Euler Nicolau Sauaia Filho²  Orlando José Dos Santos¹  Allan Kardec Duailibe Barros Filho¹  Altieres De Arruda Rocha¹  Rafael Campos Silva¹  Rayan Haquim Pinheiro Santos¹  Rennan Abud Pinheiro Santos¹ 

[1] ,Maranhao Federal University Presidente Dutra University Hospital Sao Luis MA ,Brazil

关键词: Phytotherapy;    Wound Healing;    Euphorbia;    Mice;   

DOI  :  10.1590/S0102-86502013001000005

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effects of crude extract of Euphorbia tirucalli in cutaneous wound healing. METHODS: A total of 20 Swiss mice were randomly divided into two groups, aveloz (GA) and control (CG), and each group was further divided into two subgroups based on the deaths scheduled for the 7th and 14th days after surgery. The animals underwent a resection of cutaneous fragment with 1cm in diameter on the dorsum; the GA was applied in each animal on the subsequent days, 0.1 mL (30 mg/mL) hydroalcoholic extract of Euphorbia tirucalli was applied on the wound, while the same volume of 0.9% saline solution was applied to the GC. It was evaluated the lesion diameter and after programmed death, a surgical specimen was resected for histopathology. RESULTS: In the macroscopic analysis, no statistically significant difference was observed (p = 0.120 and p = 0.186, for the 7th and 14th days of death, respectively). The histological evaluation revealed no statistically significant difference in the variables acute inflammation (p = 0.014) and fibrosis (p = 0.018), when compared the group aveloz with the control group on day 14. CONCLUSION: The crude hydroalcoholic extract of Euphorbia tirucalli L. demonstrated better outcomes in the healing process, acute inflammation and fibrosis on the 14 day postoperatively.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License