Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats

Acta Cirurgica Brasileira

José Ulisses De Souza Melo²  Radamés Bezerra Melo¹  Jefferson Menezes Viana Santos¹  Manoel Messias Campos Júnior¹  Sérgio Botelho Guimarães¹  Paulo Roberto Leitão Vasconcelos¹ 

[1] ,UFC Department of SurgeryCeara ,Brazil

关键词: Hepatectomy;    Oxidative Stress;    Liver Regeneration;    Flavonoids;    Rats;   

DOI  :  10.1590/S0102-86502013000600006

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the effect of bioflavonoid ternatin (TRT) on rat liver regeneration and oxidative stress after 70% partial hepatectomy (PH). METHODS: Thirty six young male Wistar rats were randomly assigned to two groups of 18 animals each - control (G1) and experimental (G2) - and were submitted to PH under inhalatory diethylether anesthesia. G1 rats received daily intraperitoneal (ip) injections of saline (NaCl 0.9% solution) 0.1 mL/kg for 14 days; G2 animals received daily ip injections of TRT 0.1% 1.0mg/kg for 14 days. At 36h (T1), 168h (T2) and 336h (T3) post-PH timepoints, a subgroup of six rats in each group was chosen in a randomized way to complementary hepatectomy (CH) and blood samples haversting. Collected material was saved for laboratory analysis (total bilirubin (TB), D-Glucose, glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) and assessment of liver regeneration. RESULTS: TRT induced a significant decrease in liver and plasma GSH concentrations; liver regeneration process was not affected. TRT promoted a significant decrease in blood glucose levels 168h after partial hepatectomy compared with controls. TB levels remained unchanged. CONCLUSION: Intraperitoneal bioflavonoid ternatin injection in partially hepatectomized rats induces a decrease in oxidative stress and a significant hypoglycemic state, but does not promote any change in the evolution of liver regeneration.

【 授权许可】

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