Hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage

Acta Cirurgica Brasileira

Hong Ye¹  Yingying Su² 

[1] ,Capital Medical University Xuanwu Hospital Department of NeurologyBeijing,China

关键词: Cerebral Hemorrhage;    Regional Blood Flow;    Ultrasonography;    Dopple;    Transcranial;    Mannitol;   

DOI  :  10.1590/S0102-86502013000200004

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage. METHODS: Thirty patients with acute intracerebral hemorrhage were enrolled. Transcranial doppler was used to detect variables of bilateral middle cerebral arteria (MCA) including mean velocity (Vm) and pulsitility index (PI) before and after125ml and 250ml mannitol infusion (0, 30, 60, 90, 120, 180, 240 min). RESULTS: When 125ml or 250ml mannitol was infused in patients with acute intracerebral hemorrhage, Vm of bilateral MCA elevated, and reached the top at 30min, and then decreased. PI decreased in the affected MCA (250ml) and in the unaffected MCA (125ml and 250ml). CONCLUSION: Mannitol infusion in patients with acute intracerebral hemorrhage can improve cerebral blood flow in bilateral hemispheres and decrease intracranial pressure in the hemorrhagic hemisphere (250ml) and in the nonhemorrhagic hemisphere (125ml and 250ml).

【 授权许可】

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