期刊论文详细信息
Acta Cirurgica Brasileira | |
Is there a relationship between lipids metabolism and splenic surgeries? | |
Luiz Ronaldo Alberti2  Denny Fabrício Magalhães Veloso1  Leonardo De Souza Vasconcellos2  Andy Petroianu2  | |
[1],UFMGBelo Horizonte MG ,Brazil | |
关键词: Spleen; Splenectomy; Cholesterol; Triglycerides; Rats; Baço; Esplenectomia; Colesterol; Triglicerídeos; Ratos; | |
DOI : 10.1590/S0102-86502012001100002 | |
来源: SciELO | |
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【 摘 要 】
PURPOSE: To assess the influence of spleen surgeries (splenectomy, presence of spleen and after conservative surgeries) on lipids metabolism. METHODS: Fifty female Wistar rats of similar weight and age were divided into five groups submitted to the following procedures: Group 1 - control, with an intact spleen; Group 2 - sham operation, Group 3 - total splenectomy; Group 4 - subtotal splenectomy, and Group 5 - total splenectomy complemented with autogenous spleen tissue implants. Four months after the interventions, serum triglycerides, total cholesterol and fractions (VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol) were determined. The results for the four groups were compared by analysis of variance followed by the Tukey-Kramer test, with the level of significance set at p<0.05. RESULTS: There were no differences between groups 1, 2, 4 and 5. In the animals submitted to total splenectomy, total cholesterol (p=0.0151) and LDL-cholesterol fraction concentrations (p<0.0001) were higher, whereas HDL-cholesterol fraction concentrations were lower (p=0.0026) than those detected in the other groups. There was no difference in triglycerides (p=0.1571) or VLDL-cholesterol (p=0.2527) between groups. CONCLUSION: Splenectomy is related to changes in the lipid metabolism that are reverted by autogenous spleen tissue implants.【 授权许可】
CC BY
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