Acta Cirurgica Brasileira | |
Conjunctival inflammation in patients under topical glaucoma treatment with indication to surgery | |
João Marcello Furtado1  Jayter Silva Paula2  Edson Garcia Soares2  Neifi Hassam Saloum Dhegaide1  Eduardo Melani Rocha2  Eduardo Donadi2  Maria De Lourdes Veronese Rodrigues2  | |
[1] ,USP FMRP Ribeirao Preto SP ,Brazil | |
关键词: Leukocyte Antigens; Glaucoma; Open-Angle; Immunology; Ophthalmic Solutions; Prostaglandin analogs; Antigenos Leucocitários; Glaucoma de Ângulo Aberto; Imunologia; Soluções Oftálmicas; Prostaglandinas Sintéticas; | |
DOI : 10.1590/S0102-86502012001000011 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: To compare the frequency of conjunctival HLA-DR expression (a surrogate marker for inflammation) in eyes treated with topical prostaglandin analogues versus eyes treated with other topical antiglaucomatous drugs. METHODS: Patients diagnosed with primary open-angle glaucoma presenting indication for trabeculectomy were divided in groups according to the use or not of prostaglandin analogues. All subjects were treated with the maximum tolerated dose of antiglaucomatous drugs until the date of the surgery. At the beginning of the surgical procedure, a 5 x 5 mm biopsy of the bulbar conjunctiva was collected, incubated with monoclonal anti-HLA-DR antibody and processed for histological analysis. RESULTS: Of the 31 eyes included (31 patients), 25 were under topical prostaglandin analogues (Group 1) and six under other topical pharmacological agents (Group 2). Fourteen eyes of Group 1 (56%) and three of Group 2 (50 %) were positive for the inflammatory marker HLA-DR (P=1.0). The percentage of stained cells ranged from 15.49 to 48.09% (median: 27.61) in Group 1, and from 18.35 to 28 (median: 20.71) in Group 2, with no differences statistically significant (p=0.33). CONCLUSION: The use of prostaglandin analogues did not increase conjunctival expression of HLA-DR compared to other topical antiglaucomatous agents.
【 授权许可】
CC BY
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