Conjunctival inflammation in patients under topical glaucoma treatment with indication to surgery

Acta Cirurgica Brasileira

João Marcello Furtado¹  Jayter Silva Paula²  Edson Garcia Soares²  Neifi Hassam Saloum Dhegaide¹  Eduardo Melani Rocha²  Eduardo Donadi²  Maria De Lourdes Veronese Rodrigues² 

[1] ,USP FMRP Ribeirao Preto SP ,Brazil

关键词: Leukocyte Antigens;    Glaucoma;    Open-Angle;    Immunology;    Ophthalmic Solutions;    Prostaglandin analogs;    Antigenos Leucocitários;    Glaucoma de Ângulo Aberto;    Imunologia;    Soluções Oftálmicas;    Prostaglandinas Sintéticas;   

DOI  :  10.1590/S0102-86502012001000011

来源: SciELO

【 摘 要 】

PURPOSE: To compare the frequency of conjunctival HLA-DR expression (a surrogate marker for inflammation) in eyes treated with topical prostaglandin analogues versus eyes treated with other topical antiglaucomatous drugs. METHODS: Patients diagnosed with primary open-angle glaucoma presenting indication for trabeculectomy were divided in groups according to the use or not of prostaglandin analogues. All subjects were treated with the maximum tolerated dose of antiglaucomatous drugs until the date of the surgery. At the beginning of the surgical procedure, a 5 x 5 mm biopsy of the bulbar conjunctiva was collected, incubated with monoclonal anti-HLA-DR antibody and processed for histological analysis. RESULTS: Of the 31 eyes included (31 patients), 25 were under topical prostaglandin analogues (Group 1) and six under other topical pharmacological agents (Group 2). Fourteen eyes of Group 1 (56%) and three of Group 2 (50 %) were positive for the inflammatory marker HLA-DR (P=1.0). The percentage of stained cells ranged from 15.49 to 48.09% (median: 27.61) in Group 1, and from 18.35 to 28 (median: 20.71) in Group 2, with no differences statistically significant (p=0.33). CONCLUSION: The use of prostaglandin analogues did not increase conjunctival expression of HLA-DR compared to other topical antiglaucomatous agents.

【 授权许可】

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