Expression of RANTES, eotaxin-2, ICAM-1, LFA-1 and CCR-3 in chronic rhinosinusitis patients with nasal polyposis

Acta Cirurgica Brasileira

Fransérgio Emílio Cavallari²  Fabiana Cardoso Pereira Valera²  Aline Jorge Gallego²  Rafael Rossell Malinsky²  Daniel Salgado Küpper²  Cristiane Milanezi¹  João Santana Da Silva¹  Edwin Tamashiro²  Wilma Terezinha Anselmo-lima² 

[1] ,USP Faculty of Medicine of Ribeirao Preto Department of Ophtalmology, Otorhinolaryngology and Head and Neck SurgerySao Paulo SP ,Brazil

关键词: Nasal Polyps;    Chemokines;    Intercellular Adhesion Molecule-1;    Sinusitis;    Pólipos Nasais;    Quimiocinas;    Molécula 1 de Adesão Intercelular;    Sinusite;   

DOI  :  10.1590/S0102-86502012000900010

来源: SciELO

【 摘 要 】

PURPOSE: To compare gene expression of the chemokines RANTES and eotaxin-2, its receptor, CCR-3, adhesion molecule ICAM-1 and its receptor LFA-1 in eosinophilic polyps and in control normal nasal mucosa. METHODS: Gene expression was quantified by Real Time PCR in polyps (n=35) and in healthy nasal mucosa (n=15). RESULTS: Eosinophilic polyps showed a higher expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa. CONCLUSION: Eosinophilic polyps present greater expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa.

【 授权许可】

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