Acta Cirurgica Brasileira | |
A novel model of distal colon cancer in athymic mice | |
Denise Gonçalves Priolli2  Ana Margarida Abrantes1  Silvia Neves1  Joana Neves Batista1  Izilda Aparecida Cardinalli2  Maria Filomena Botelho1  | |
[1] ,Sao Francisco University Medical School Bragança Paulista SP ,Brazil | |
关键词: Xenograft Model Antitumor Assays; Colorectal Neoplasms; Radionuclide Imaging; Technetium Tc 99m Sestamibi; Mice; Nude; Ensaios Antitumorais Modelo de Xenoenxertos; Neoplasias Colorretais; Cintilografia; Tecnécio Tc 99m Sestamibi; Camundongos Nus; | |
DOI : 10.1590/S0102-86502012000600001 | |
来源: SciELO | |
【 摘 要 】
PURPOSE: The present a novel adenocarcinoma model in athymic mice. METHODS: Seven athymic mice were used. Colon diversion and distal fistula were made. Adenocarcinoma cells were inoculated in the submucosa of fistula. Tumor growth was monitored daily. Scintigraphy with 99mTc-MIBI was performed to identify the tumor. RESULTS: The model of distal colon cancer is feasible. Tumor detection was possible by both, macroscopically and molecular imaging. All resections demonstrated poorly differentiated tumors. Colon obstruction occurred in one case, similarly to evolution in human tumors of distal colon. CONCLUSION: The proposed model of distal colon cancer is feasible, allows for easy monitoring of tumoral growth by both, macroscopically and molecular imaging, and is suitable for studying the evolution of tumor with implementation of cytotoxic therapy in vivo.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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