Effect of a hyperlipidic diet rich in omegas 3, 6 and 9 on aberrant crypt formation in rat colonic mucosa

Acta Cirurgica Brasileira

Idália Maria Brasil Burlamaqui¹  Conceição Aparecida Dornelas²  José Telmo Valença Júnior²  Daniel Magalhães Coutinho Mota¹  Francisco José Cabral Mesquita¹  Lara Burlamaqui Veras¹  Paulo Roberto Leitão Vasconcelos²  Lusmar Veras Rodrigues² 

[1] ,UFC,Brazil

关键词: Dietary Fats;    Unsaturated;    Azoxymethane;    Colorectal Neoplasms;    Aberrant Crypt Foci. Rats;    Gorduras Insaturadas na Dieta;    Azoximetano;    Neoplasias Colorretais;    Focos de Criptas Aberrantes;    Ratos;   

DOI  :  10.1590/S0102-86502012000100006

来源: SciELO

【 摘 要 】

PURPOSE: To determine whether a hypercaloric and hyperlipidic diet enriched with polyunsaturated fatty acids influences the formation of aberrant crypt foci (ACF) in colonic mucosa of Wistar rats treated with azoxymethane (AOM). METHODS: At eight weeks of life, the rats were assigned to four groups: Group I―standard diet (STD) not treated with AOM; Group II―hypercaloric and hyperlipidic diet (FED), not treated with AOM; Group III―STD, treated with AOM; Group IV―FED, treated with AOM. At 16 weeks, the animals were injected intraperitoneal with 0.9% saline solution (Group I and II) or AOM at 15mg/Kg (Groups III and IV) once a week for two weeks. Fifteen weeks later, the animals were euthanized. RESULTS: FED promoted weight gain in Groups II and IV compared to Groups I and III, respectively. The groups did not differ with regard to the total number of ACF. The Chi-square test revealed no predominance of the presence of foci with <4 crypts. However, foci with ≥5 crypts were proportionally more prevalent in Group III than in Group IV (p=0.043). CONCLUSION: The administration of polyunsaturated fatty acids did not interfere with the formation of aberrant crypt foci, but reduced ACF multiplicity, exercising an attenuating effect on carcinogenesis.

【 授权许可】

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