Changes caused by hidrocephalus, induced by kaolin, in the corpus callosum of adult dogs

Acta Cirurgica Brasileira

Edvaldo José Rodrigues Cardoso¹  João José Lachat²  Luiza Silva Lopes¹  Antonio Carlos Dos Santos¹  Benedicto Oscar Colli¹ 

[1] ,USP FMRP Department of Surgery and AnatomyRibeirao Preto Sao Paulo ,Brazil

关键词: Hydrocephalus;    Corpus Callosum;    Myelin Sheath;    Dogs;    Hidrocefalia;    Corpo Caloso;    Bainha de Mielina;    Cães;   

DOI  :  10.1590/S0102-86502011000800003

来源: SciELO

【 摘 要 】

PURPOSE: To analyze the ventricular enlargement and myelination of the corpus callosum in adult dogs after four and eight weeks of kaolin-induction of hydrocephalus. METHODS: 36 dogs were randomly divided into 3 groups: 1 - without hydrocephalus, 2 - kaolin-induction of hydrocephalus until the fourth week, and 3 - kaolin-induction of hydrocephalus until the eighth week. Ventricular ratios and volumes were calculated using magnetic resonance images, and myelination of the corpus callosum were histologically evaluated using solocromo-cianin stain. RESULTS: Radiological hydrocephalus was observed in 93.75% and overall mortality was 38.4%. Ventricular volumes and ratios were higher in groups 2 and 3 compared to group 1 and similar when measures in the fourth and eighth weeks were compared in the group 3. Indices of luminescence in the knee and in the splenium of the corpus callosum were higher in group 2 than in group 1 indicating that there was loss of myelin in group 2, and similar in groups 1 and 3, showing a tendency to remyelination after 8 weeks. CONCLUSION: The corpus callosum of dogs with kaolin-induced hydrocephalus responds with demyelination of the knee and splenium by the fourth week with a tendency to remyelination by the eighth week.

【 授权许可】

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