Profile of wound healing process induced by allantoin

Acta Cirurgica Brasileira

Lorena Ulhôa Araújo²  Andrea Grabe-guimarães¹  Vanessa Carla Furtado Mosqueira¹  Claudia Martins Carneiro¹  Neila Márcia Silva-barcellos¹ 

[1] ,UFOPOuro Preto MG ,Brazil

关键词: Wound Healing;    Allantoin;    Histology;    Animal Experimentation;    Rats;    Cicatrização de Feridas;    Alantoína;    Histologia;    Experimentação Animal;    Ratos;   

DOI  :  10.1590/S0102-86502010000500014

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate and characterize the wound healing process profile induced by allantoin incorporated in soft lotion oil/water emulsion using the planimetric and histological methods. METHODS: Female Wistar rats (n=60) were randomly assigned to 3 experimental groups: (C) control group-without treatment; (E) group treated with soft lotion O/W emulsion excipients; (EA) group treated with soft lotion O/W emulsion containing allantoin 5%. The emulsions either containing or not allantoin were topically administered for 14 days and the wound area was evaluated by planimetry and by qualitative and quantitative histological analysis of open wound model. RESULTS: The data which were obtained and analyzed innovate by demonstrating, qualitatively and quantitatively, by histological analysis, the profile of healing process induced by allantoin. The results suggest that the wound healing mechanism induced by allantoin occurs via the regulation of inflammatory response and stimulus to fibroblastic proliferation and extracellular matrix synthesis. CONCLUSION: This work show, for the first time, the histological wound healing profile induced by allantoin in rats and demonstrated that it is able to ameliorate and fasten the reestablishment of the normal skin.

【 授权许可】

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