The effect of anti-hypertensive drugs on the obstructive pancreatitis in rats

Acta Cirurgica Brasileira

Roberto De Barros Silva²  Fernando Silva Ramalho¹  Leandra Z. Naira Ramalho¹ 

[1] ,USP Faculty Medicine of Ribeirao Preto Department of Pathology and Forensis MedicineSao Paulo,Brazil

关键词: Pancreatitis;    Receptors;    Angiotensin;    Antihypertensive Agents;    Rats;    Pancreatite;    Receptores de Angiotensina;    Anti-Hipertensivos;    Ratos;   

DOI  :  10.1590/S0102-86502010000500003

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the effect of ACE inhibitor, lisinopril and AT1 blocker, losartan, on the obstructive pancreatitis in rat. METHODS: Acute pancreatitis in rats (n=21) was induced for a common hepatic duct were ligated proximal to its entry into the pancreas and the common bile - pancreatic duct were also ligated near its junction with the duodenum, under ether anesthesia, after which the abdomen were closed. The animals was divided in tree groups, being two treated and control group. The animals was treated with Losartan and Lisinopril at the dose of 10µg/Kg body weight per day, i.p., in a proportional volume, for five days, before and after treatement. RESULTS: The inflammation, collagen deposition in the pancreas of treated animals were smaller, suggesting that the use of antihypertensive agents interfered positively in the depletion of the injury of the pancreas. Scythe showed a correlation between activity of pancreatic stellate cells (PSCs) lower in treated animals when compared to control. CONCLUSION: The pancreatic stellate cells strength are involved in collagen production during acute pancreatitis and why antihypertensive drugs such as lisinopril and losartan may possibly have beneficial effects in reducing pancreatic fibrosis in models of experimental obstructive pancreatitis.

【 授权许可】

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