Porcine peritoneum as source of biocompatible collagen in mice

Acta Cirurgica Brasileira

Cristina Jardelino²  Esther Rieko Takamori¹  Luiz Felipe Hermida¹  Ariel Lenharo¹  Igor Iuco Castro-silva¹  Jose Mauro Granjeiro¹ 

[1],UFF Dental School Program in DentistryRio de Janeiro,Brazil

关键词: Materials Testing;    Biocompatible Materials;    Subcutaneous Tissue;    Peritoneum;    Mice;    Teste de Materiais;    Materiais Biocompatíveis;    Tela Subcutânea;    Peritônio;    Camundongos;   

DOI  :  10.1590/S0102-86502010000400006

来源: SciELO

【 摘 要 】

PURPOSE: To investigate the biocompatibility and biodegradability of a membrane made from porcine peritoneum. METHODS: The membrane (5x5 mm) was inserted in the subcutaneous tissue on the back of 15 mice, which were killed after 1, 3 and 9 weeks (ISO 10993-6). The cellular components of the inflammatory response and degradation of the membrane were analyzed in hematoxylin-eosin-stained histological sections. RESULTS: After one week, mononuclear cells were observed inside the membrane. After three weeks, the material was almost completely absorbed. After nine weeks, there was no presence of material and there were signs of tissue remodeling. There was neither a foreign body reaction nor signs of tissue necrosis. CONCLUSION: The collagen membrane derived from porcine peritoneum is biocompatible and bioabsorbable when implanted in the subcutaneous tissue of mice.

【 授权许可】

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