Platelet-rich plasma in bone repair of irradiated tibiae of Wistar rats

Acta Cirurgica Brasileira

Emne Hammoud Gumieiro²  Márcio Abrahão¹  Ricardo Schmitutz Jahn¹  Helena Segretto¹  Maria Tereza De Seixas Alves¹  Ulf Nannmark¹  Gösta Granström¹  Luciano Lauria Dib¹ 

[1] ,UNIFESP Department of Otorhinolaringology and Head and Neck SurgerySão Paulo ,Brazil

关键词: Platelet-Rich Plasma;    Radiation Injuries;    Experimental;    Bone Regeneration;    Plasma Rico em Plaquetas;    Lesões Experimentais por Radiação;    Regeneração Óssea;   

DOI  :  10.1590/S0102-86502010000300007

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the influence of PRP addition on bone repair of circular defects created in irradiated tibiae of rats by histometric analysis. METHODS: Sixty male Wistar rats had the right tibiae irradiated with 30 Gy. After 30 days monocortical defects were created and platelet-rich plasma was applied in 30 rats. In the control group defects were created but not filled. The animals were desanguinated after 4, 7, 14, 21, 56 and 84 days and the tibiae removed for histological processing. RESULTS: There was a tendency in the PRP group to increased bone neoformation from 14-days to 84-days; in the control group increased bone neoformation was not seen after 21 days or later. CONCLUSION: The addition of platelet-rich plasma had a beneficial effect in the initial cellular regeneration period and enhanced bone formation in later periods when compared to control.

【 授权许可】

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