The effect of copaiba balsam on Walker 256 carcinoma inoculated into the vagina and uterine cervix of female rats

Acta Cirurgica Brasileira

Nara Macedo Botelho Brito²  Marcus Vinicius Henriques Brito¹  Rita De Kássia Vidigal Carvalho¹  Lia Tavares De Moura Brasil Matos¹  Rodolfo Costa Lobato¹  Suelen Costa Correa¹  Rosângela Baía Brito¹ 

[1],UEPA Department of Specialized Health Pará,Brazil

关键词: Plants;    Medicinal;    Carcinoma 256;    Walker;    Uterine Cervical Neoplasms;    Rats;    Plantas Medicinais;    Carcinoma 256 de Walker;    Neoplasias do Colo do Útero;    Ratos;   

DOI  :  10.1590/S0102-86502010000200010

来源: SciELO

【 摘 要 】

PURPOSE: To verify the copaiba balsam (Copaifera officinalis) effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats. METHODS: Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC). On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2x10(6) concentration) was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba balsam to the GCop group. On the 12th day, euthanasia was performed and the tumor was grafted, being weighted and verified its volume. The data were submitted to statistical analysis with ANOVA test. RESULTS: It was observed that copaiba balsam presented a negative inhibitory potential of 70%. CONCLUSION: The copaiba balsam stimulated the tumor growth.

【 授权许可】

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