Chemoprevention by celecoxib in reflux-induced gastric adenocarcinoma in Wistar rats that underwent gastrojejunostomy

Acta Cirurgica Brasileira

Frederico Theobaldo Ramos Rocha²  Laercio Gomes Lourenço¹  Mário Jorge Jucá¹  Valéria Costa¹  Antenor Teixeira Leal¹ 

[1] ,Federal University of Alagoas Department of Surgery ,Brazil

关键词: Adenocarcinoma;    Stomach;    Chemoprevention;    Cyclooxygenase inhibitors;    Rats;    Adenocarcinoma;    Estômago;    Quimioprevenção;    Inibidores de ciclooxigenase;    Ratos;   

DOI  :  10.1590/S0102-86502009000300005

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate chemoprevention by celecoxib in cases of reflux-induced gastric adenocarcinoma, in Wistar rats that underwent gastrojejunostomy. METHODS: Sixty male Wistar rats of average age three months underwent surgery and were distributed into three groups: group 1, exploratory laparotomy; group 2, gastrojejunostomy; and group 3, gastrojejunostomy and daily celecoxib administration. After 53 weeks, the animals were sacrificed. Changes in the mucosa of the gastric body of group 1 and in the gastrojejunal anastomosis of groups 2 and 3, observed in histopathological and immunohistochemical examinations, were compared. All statistical analyses were performed using Epi-Info®, version 3.4.3. RESULTS: Comparison between groups 2 and 3 relative to the presence of adenocarcinoma showed a statistically significant difference (p=0.0023). Analysis of the association between groups 2 and 3 relative to COX-2 expression also showed a statistically significant difference (p=0.0018). CONCLUSION: Celecoxib had an inhibiting effect on gastric carcinogenesis induced by enterogastric reflux in an animal model.

【 授权许可】

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