Assessment of serum enzymatic markers of cardiomyocytes injury in female dogs submitted to ketamine S(+), atropin and xylazine association

Acta Cirurgica Brasileira

Leandro Guimarães Franco²  Maria Clorinda Soares Fioravanti¹  Adilson Donizeti Damasceno¹  Aline Cardoso Borges¹  Lorena Karine Soares¹  Rogério Elias Rabelo¹  Luiz Antônio Franco Da Silva¹ 

[1] ,UFG Veterinary College Post Graduation Program in Animal Science Goias ,Brazil

关键词: Isoenzymes;    Atropine;    Xylazine;    Heart;    Ischemia;    Anesthetics;    Dissociative;    Dogs;    Isoenzima;    Atropina;    Xilazina;    Coração;    Isquemia;    Anestésicos Dissociativos;    Cães;   

DOI  :  10.1590/S0102-86502009000100008

来源: SciELO

【 摘 要 】

PURPOSE: To assessment of the aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase isoenzyme fraction MB (CK-MB) serum activity in female dogs anesthetized with ketamine S (+), atropine and xylazine in several associations. METHODS: Twenty three healthy female dogs randomly distributed in four groups named as GI (n=6), GII (n=6), GIII (n=6) and GIV (n=5) were treated respectively with atropine and ketamine S(+) (0.04mg/kg; 10 mg/kg); ketamine S(+) (10 mg/kg); atropine, xylazine and ketamine S(+) (0.04mg/kg; 1.1 mg/kg; 10 mg/kg) and xylazine and ketamine S(+) (1.1 mg/kg; 10 mg/kg). AST, CK and CK-MB serum activity measurement before pre-medication (M0) and one, two, three, six, 12, 24, 36 hours after. RESULTS: There was no significant change in AST, CK e CK-MB serum activity among groups. However, CK serum activity in relation to moments within the groups was increased in all groups over the time in spite of treatment, except GI. In relation to CK-MB activity, in the moments within the group, it was observed an increase compared to baseline in all groups. CONCLUSION: Creatine kinase and creatine kinase fraction MB isoenzyme showed changes in their mean values remained higher than baseline for a longer time in GIII and GIV.

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