The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats

Acta Cirurgica Brasileira

Nara Macedo Botelho Brito²  Rita De Kássia Vidigal Carvalho¹  Lia Tavares De Moura Brasil Matos¹  Rodolfo Costa Lobato¹  Rosângela Baía Brito¹ 

[1] ,UEPA Department of Specialized HealthPara ,Brazil

关键词: Ovariectomy;    Cervix Uteri;    Vagina;    Carcinoma 256;    Walker;    Rats;    Ovariectomia;    Colo do Útero;    Vagina;    Carcinoma 256 Walker;    Rats;   

DOI  :  10.1590/S0102-86502009000100006

来源: SciELO

【 摘 要 】

PURPOSE: Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats. METHODS: Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG): Rats inoculated with Walker 256 tumor; Oophorectomy group (OG): oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following day, the vaginal walls were scarified with an endocervix brush, and then Walker 256 tumor was inoculated. After 12 days, the tumor was removed together with the vagina and uterine horns for macro and microscopic analyses. The data were submitted to statistical analyses. RESULTS: There was no statistical difference between the two groups; however it was observed that the behavior of tumor growth on the OG group presented greater invasion, compromising the uterine horns. CONCLUSION: The results of the study on the GO group presented a macroscopic behavior different from the TG group, however, both of them presented similar development in terms of tumor mass.

【 授权许可】

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