The role of hyperbaric oxygen therapy (HOT) as an otoprotection agent against cisplatin ototoxicity

Acta Cirurgica Brasileira

Camila C. Yassuda²  Ana Elisa M. Righetti²  Maria Cristina L. Cury¹  Miguel Ângelo Hyppolito¹  José Antonio A. De Oliveira¹  Omar Féres¹ 

[1] ,University of São Paulo Ribeirao Preto Faculty of Medicine ,Brazil

关键词: Hyperbaric Oxygen Therapy;    Ototoxicity;    Otoprotection;    Cisplatin;    Oxigenoterapia Hiperbárica;    Ototoxicidade;    Otoprotecão;    Cisplatina;   

DOI  :  10.1590/S0102-86502008000700013

来源: SciELO

【 摘 要 】

PURPOSE: Hyperbaric oxygen therapy (HOT) consists of intermittent inhalations of 100% oxygen at a pressure higher than 1 atm. It is an important adjuvant therapy in pathological processes like soft tissue infections, radiation injury, gas gangrene, osteomyelitis and decompressive diseases. Cisplatin, a potent antineoplastic drug, widely used in cancer therapy is highly ototoxic causing bilateral, irreversible damage to the hearing of high frequency sounds (4-8 KHz). OBJECTIVE:This experimental study conducted at the Faculty of Medicine of Ribeirao Preto, University of Sao Paulo aims to evaluate Hyperbaric Oxygen Therapy as an otoprotection agent against drug toxicity. METHODS: Albino guinea pigs were divided into two groups: in Group A, 5 animals (10 cochlea) received cisplatin, i. p., 8.0 mg/kg/day during three days and afterwards were submitted to HOT; in Group B, 3 animals (6cochlea) received cisplatin, i. p. 8.0mg/kg/day during three days. Guinea pigs were evaluated by acoustic otoemissions (AOE) and scanning electron microscopy (SEM). RESULTS: Group B animals showed loss of auditory functions as measured by AOE and distorted outer hair cells by SEM. In Group A, outer hair cells shown by SEM images were mostly preserved. CONCLUSION: It is presumed that Hyperbaric Oxygen Therapy has a protector effect against cisplatin ototoxicity.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License