Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model

Acta Cirurgica Brasileira

Antonio Roberto Franchi Teixeira²  Nilza Trindade Molan¹  Marta Bellodi-privato¹  Ana Maria Coelho¹  Kátia Ramos Leite¹  Antônio Carlos Seguro¹  Telésforo Bacchella¹  Marcel Cerqueira César Machado¹ 

[1],USP School of Medicine Department of Gastroenterology,Brazil

关键词: Ischemia;    Reperfusion;    Liver;    Rats;    Isquemia;    Reperfusão;    Fígado;    Ratos;   

DOI  :  10.1590/S0102-86502008000400013

来源: SciELO

【 摘 要 】

PURPOSE: To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats. METHODS: Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification. RESULTS: There were no statistical differences between groups for all analysed parameters. CONCLUSION: In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.

【 授权许可】

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