Fibrosis in tubularized skin flaps in rats, using silicon catheters with two different degrees of flexibility: experimental model

Acta Cirurgica Brasileira

Antonio Henrique Rodrigues Dos Passos²  Fernando Costa¹  Lúcio Tedesco Marchese¹  Sergio Augusto Catanzaro Guimarães¹  Wilson Aparecido Oreini¹ 

[1] ,College of Medicine of Marília Division of Pediatric SurgerySão Paulo ,Brazil

关键词: Hypospadias;    Surgical Flaps;    Silicon;    Fibrosis;    Rats;    Hipospadia;    Retalhos Cirúrgicos;    Silicones;    Fibrose;    Ratos;   

DOI  :  10.1590/S0102-86502008000300005

来源: SciELO

【 摘 要 】

PURPOSE: Microscopically evaluate the intensity of fibrosis in tubularized skin flaps on the back of Wistar rats, using silicon molds with different degrees of flexibility. METHODS: Twenty rats were submitted to three tubularized skin flaps on their backs. In two tubular flaps, we placed, as a mold, silicon catheters with different degrees of flexibility and removed them on the seventh day after the surgery. They were divided into two groups and euthanized, on the seventh and twenty-first days respectively after the surgery for the collection of the pieces, coloration with Masson tricromic, quantification of the area of each sample and comparison among the groups. RESULTS: Fibrosis was less intense on the tubular flaps where a catheter was not used as a mold. No significant difference was verified among the pieces with the silicon catheters, but there was a tendency of less fibrosis on the tubules with the most flexible catheter. CONCLUSION: There was no significant difference among the two catheter types. Fibrosis was less intense in the flaps where the mold was not used.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License