Morphometric analysis of intimal thickening secondary to stent placement in pig carotid arteries

Acta Cirurgica Brasileira

Márcio Bastiani Pasa²  Adamastor Humberto Pereira¹  Cyro Castro Júnior¹ 

[1] ,Rio Grande do Sul Federal University Medicine School Post-Graduate Program

关键词: Stents;    Constriction;    Pathologic;    Vascular Diseases;    Animal Experimentation;    Contenedores;    Constrição Patológica;    Doenças Vasculares;    Experimentação Animal;   

DOI  :  10.1590/S0102-86502008000200009

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate intimal thickening secondary to stent placement or to insertion of the delivery system without stent placement in pig carotid arteries. METHODS: Stents were placed in the right common carotid arteries of 7 pigs, and 7 other control pigs underwent only insertion of the delivery system without stent placement. Uninjured contralateral common carotid arteries of the two groups were also used as controls. Samples of arterial tissue, obtained from the area adjacent to the distal segment of the stent four weeks after placement, underwent morphometric analysis. Morphometric data were compared with findings for arterial samples from injured arteries of the control group and uninjured contralateral arteries of the two groups. The unpaired Mann-Whitney U test and the Wilcoxon t test for nonparametric samples were used for statistical analysis. RESULTS: Greater intimal thickening was found in the group in which stents were placed (p=0.008). Changes in luminal area and media layer were not significantly different between the two groups. The comparison of contralateral carotid arteries of the two groups revealed significant changes in intimal and luminal areas. No statistically significant changes were found in medial layer area. CONCLUSIONS: All arteries that underwent stent placement showed intimal thickening without changes in the tunica media at four weeks. Dissection and insertion of the delivery system without stent placement was associated with a lesser degree of intimal thickening.

【 授权许可】

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