Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration

Acta Cirurgica Brasileira

Jair Francisco De Santana Graim²  Gaspar De Jesus Lopes Filho¹  Marcus Vinicius Henriques Brito¹  Lia Tavares De Moura Brasil Matos¹ 

[1] ,State University of Pará Integrated Health Department ,Brazil

关键词: Plants;    Medicinal;    Liver;    Phytotherapic Drugs;    Rats;    Plantas Medicinais;    Fígado;    Medicamentos Fitoterápicos;    Ratos;   

DOI  :  10.1590/S0102-86502008000200004

来源: SciELO

【 摘 要 】

PURPOSE: To evaluate the hepatic effect of Croton cajucara Benth (sacaca) herbal extract in rats. METHODS: 60 Wistar rats (Rattus novergicus albinus) were used, weighing between 250 and 350 g. The animals were distributed randomically in 2 groups: GS - animals which received daily 0,1 ml/ 100 g of sacaca herbal extract through gavage, and GA -animals which received daily 0,1 ml/100g of distilled water through gavage. These were distributed in 3 subgroups with 10 animals, according to theirs euthanasia dates, which were 14th, 28th and 56th day of treatment. RESULTS: Architectural alterations were not observed, however when it was analyzed the presence or absence of necrosis, it was observed in 50% of GS28 subgroup and 90% of subgroup. In 50% of the animals from GS28 subgroup and 90% of GS56 subgroup was observed vast degeneration areas and zonal necrosis, regarding center-lobular veins alterations, there were no alterations in any of the groups CONCLUSION: The Croton cajucara Benth (sacaca) herbal extract in this experiment caused degeneration and hepatic necrosis, suggesting dose-dependent action.

【 授权许可】

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