Histological study on acute inflammatory reaction to polyurethane-coated silicone implants in rats

Acta Cirurgica Brasileira

Paulo Roberto Da Silva Mendes²  Jorge Bins-ely¹  Eduardo Arnaut Dos Santos Lima²  Zulmar Antonio Accioli De Vasconcellos¹  Armando José D'acampora¹  Rodrigo D' Eça Neves¹ 

[1] ,University HospitalSanta Catarina,Brazil

关键词: Implants;    Silicone;    Polyurethane;    Staphylococcus cutaneous infections;    Wistar Rats;    Implante;    Silicone;    Poliuretanos;    Infecções cutâneas estafilocócicas;    Ratos de Wistar;   

DOI  :  10.1590/S0102-86502008000100015

来源: SciELO

【 摘 要 】

PURPOSE: Evaluating histologically the silicone peri-implant coated by polyurethane inflammation associated to the use of anti-microbial and bacterial contamination. METHODS: It was used 35 Wistar rats. The animals were divided in seven groups: I - Control; II - implant cavity contamination with10 bacteria/ml; III - implant cavity contamination with 10 bacteria/ml; IV - implant cavity contamination with 10 bacteria/ml; V - identical contamination to group II and implant immersions in anti-microbial solution; VI - identical contamination in group III and implant immersions in the anti-microbial solution; VII - identical contamination of group IV and implant immersions in anti-microbial solution. It was evaluated morphometrically the peri-implant capsules after 30 days of introduction. RESULTS: The factors with more discriminating power were the giants cells of a strange body and the mononuclear. There was no correlation between the bacterial concentrations and the histological alterations. CONCLUSION: 1) The histological standard of the inflammatory reaction around the silicone implant coated with polyurethan is chronic granulomatosis type of a strange body; 2) There isn´t correlation between concentration of Staphylococcus epidermidis and histological changes; 3) The use of anti-microbial solution decreased the mononuclear cell reactions, with the increase of giant cells in a strange body.

【 授权许可】

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