The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury

Acta Cirurgica Brasileira

Márcio Benedito Palma Pimenta²  José Eduardo De Aguilar-nascimento²  Dely Cristina Martins¹  Daniele Ribastski Da Silva¹  Kátia Leston Bacelo¹  Isabel Cristina Bocchese¹  Sarai Zaffani¹  Elieser Zaffani¹  Érika Alessandra Oliveira Silveira¹  Aracelle Victor Do Carmo¹  Simone Sampaio Saldanha Ferreira¹ 

[1] ,Federal University of Mato Grosso Department of Surgery ,Brazil

关键词: Ischemia;    IL-6;    C-reactive protein;    Mucosa;    Inflammation;    Isquemia;    IL-6;    Proteina C-reativa;    Mucosa;    Inflamação;   

DOI  :  10.1590/S0102-86502007000700008

来源: SciELO

【 摘 要 】

PURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP). RESULTS: Serum IL-6 at the heart (223.6±197.9 [10-832] pg/mL) was higher (p<0.001) than at both portal (133.08±108.52 [4-372] pg/mL) and posterior cava veins (127.58±109.15 [8-388] pg/mL). CRP was not significant different among groups. CONCLUSION: The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.

【 授权许可】

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