1.8 cineole decreases gastric compliance in anesthetized rats

Acta Cirurgica Brasileira

José Ricardo Cunha Neves²  Gislano Heverton Soares De Lira²  Rocino Marinho De Oliveira Neto²  José Ronaldo Vasconcelos Da Graça²  Paulo Roberto Leitão De Vasconcelos²  Miguel Ângelo Nobre E Souza¹  Pedro Jorge Caldas Magalhães¹  Francisco Hélio Rola²  Armênio Aguiar Dos Santos² 

[1] ,UFCSobral,Brazil

关键词: Croton;    Gastrointestinal Motility;    Stomach;    Rats;    Croton;    Motilidade Gastrointestinal;    Estômago;    Ratos;   

DOI  :  10.1590/S0102-86502007000100012

来源: SciELO

【 摘 要 】

PURPOSE: To study the effect of 1,8 cineoleee components of the essencial oil of Croton nepetaefolius - plant of North-East of Brasil, used in the popular medicine for riots of the gastrointestinal tract - on the motor behavior of the gut of Wistar rats. METHODS: Used 16 male animals under jejun of 24h weighing 300-350g. The effect of 1.8 cineoleee (1 or 3mg/Kg) on gastric compliance had been lead in anaesthetized rats. The variations of the gastric volume (GV), had been measured by plethysmography, while AP, HR and CVP had been monitored continuously by a digital system of data acquisition. RESULTS: Observe reduction of the GV, which was significant on 30, 40, 50 and 60min after treatment (2.0±0.1; 1.9±0.1; 1.8±0.1 and 1.7±0.1mL, versus 2.1±0.2mL). The AP presented significant fall after the administration of 1.8 cineoleee, remaining thus during 60min of monitorization (87.9±7.7; 87.6±7.1; 87.9±6.4; 87.8±5.7; 86.0±5.5 and 87.7±6.0mmHg, respectively versus 94.4±6.2 mmHg), as well as the HR (366.3±13.4; 361.7±11.5; 357.3±10.4; 353.0±10.4; 348.3±11.1 and 350.4±13.7bpm, respectively versus 395.2±11.1bpm). The CVP did not suffer significant variations after treatment. CONCLUSION: Observe the 1.8 cineoleee reduces the gastric compliance in anaesthetized rats besides presenting effect hipotensor and bradicardic; probably for direct action on the gastrointestinal and vascular smooth muscel and moduling the autonomic nervous system.

【 授权许可】

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