A study of the effects of pinealectomy on intestinal cell proliferation in infant newborn rats

Acta Cirurgica Brasileira

Marcelo Belini Dalio²  Luis Fernando Haikel Júnior²  Renato Belini Dalio²  André Pera Marques Pinto²  Júlio César Fernandes Da Silva¹  Marcelo Vinícius Oliveira Vespúcio¹  Marco Aurélio Guimarães¹  Sérgio Britto Garcia¹ 

[1] ,USP FMRP University Hospital

关键词: Pineal Gland;    Intestine;    Small;    Instestine;    Large;    Infant;    Newborn;    Rats;    Glândula Pineal;    Intestino Delgado;    Intestino Grosso;    Recém-Nascido;    Ratos;   

DOI  :  10.1590/S0102-86502006000100005

来源: SciELO

【 摘 要 】

PURPOSE: Study the proliferation rate of jejunum and large intestine crypt epithelial cells, in rats pinealectomized immediately after borning. METHODS: Twenty-four male Wistar rats were distributed into two groups: Acute group (n=12) and Chronic group (n=12). Six animals of each group were operated for removal of the pineal gland (pinealectomy-PnX), and other six were controls (sham pinealectomy-C). Animals from acute and chronic group were sacrificed 15 and 90 days after the surgery, respectively. RESULTS: In acute group, pinealectomy of new-born rats has not caused significant alteration in cell proliferation (PnX=58,77±1,77 and C=60,88±1,10 in the descending colon/ PnX=31,56±0,45 and C=31,73±0,47 in the proximal jejunum) and in crypt cell population (PnX=24,92±4,82 and C=23,60±2,48 in the descending colon/ PnX=39,92±3,49 and C=44,32±5,56 in the proximal jejunum). However, in chronic group there was an uprising crypt cell production per crypt in the proximal jejunum (PnX=57,54±2,19 and C=47,19±7,3)and in the descending colon (PnX=37,78±2,22 and C=17,92±2,28). CONCLUSION: As the increase of intestinal crypts epithelial cells in chronic group is a carcinogenesis predetermining factor, the understanding of the interaction between pineal gland and this event has great importance.

【 授权许可】

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