Detection of CD5 in B-cell chronic lymphoproliferative diseases by flow cytometry: a strong expression in B-cell chronic lymphocytic leukemia

Acta Cirurgica Brasileira

Geraldo Barroso Cavalcanti Júnior²  Valeria Soraya De Farias Sales²  Dany Geraldo Kramer Cavalcanti E Silva¹  Maria Cleide De Araújo Lopes¹  Aldair De Souza Paiva¹  Henrique Eduardo Macedo Da Fonseca¹  Francisco Fernandes Do Nascimento Júnior¹  Maria Zélia Fernandes¹ 

[1] ,Universidade Federal do Rio Grande do Norte Departamento de Análises Clínicas e Toxicológicas Natal RN ,Brazil

关键词: CD5;    B cell;    Chronic lymphocytic leukemia;    B-cell prolymphocytic leukemia;    Hairy cell;    Mantle cell lymphoma;    CD5;    Leucemia linfocítica crônica;    Células B;    Linfoma;    Células do manto;   

DOI  :  10.1590/S0102-86502005000700011

来源: SciELO

【 摘 要 】

PURPOSE: CD5 is a T cell marker, aberrantly express in B cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL). Other chronic B cell malignancies including hairy cell leukemia (HCL) and B cell prolymphocytic leukemia (B-PLL) are CD5 negative or express this antigen in a weak way. In this study, CD5 expression was investigated in leukemic cells from 42 patients with chronic B cell lymphoproliferative disease. METHODS: We studied the CD5 expression in leukemic cells from 42 patients with chronic B-cell malignancies by flow cytometry. Demographic features such as age, sex and clinical date were also analyzed. RESULTS: There were 22 males and 20 females. The immunophenotyping showed that 35 cases were B-CLL, 3 B-PLL and HCL and one patient was MCL. CD5 expression was present in all B-CLL and MCL. Low expression of CD5 was observed in one patient with B-PLL and negative in all cases of HCL. CONCLUSION: Our date demonstrated that CD5 expression can help distinguish among B-CLL from HCL and B-PLL, but is similar expressed in MCL.

【 授权许可】

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