Experimental model of gastroesophageal reflux in rats

Acta Cirurgica Brasileira

Edmilson Vieira Gaia Filho²  Alberto Goldenberg¹  Henrique Oliveira Costa² 

[1] ,UNCISAL Escola de Ciências Médicas de Alagoas

关键词: Gastroesophageal Reflux;    Esophagitis;    Peptic;    Animal Experimentation;    Refluxo Gastroesofágico;    Esofagite Péptica;    Experimentação Animal;   

DOI  :  10.1590/S0102-86502005000600008

来源: SciELO

【 摘 要 】

PURPOSE: To develop an experimental model of gastroesophageal reflux in rats. METHODS: Sixty Wistar rats underwent surgery and were assigned to one of the three groups of twenty animals each. The animals in group A underwent total esophageal myectomy and, in group (B), underwent partial myectomy. The third group was the control group (C). A contrast radiographic study of the esophagus was performed to evaluate gastroesophageal reflux. The anatomopathological study of the esophagus was used to evaluate esophagitis. RESULTS: During the 30-day postoperative follow-up, 14 animals in group A presented with reflux of barium in the esophagus. The presence of barium in the esophagus was observed in 7 animals in group B and in 2 animals in the control group. The result of the histopathology examination was controversial. A marked weight loss in the rats undergoing total myectomy was observed, however there was no significant statistical difference. CONCLUSION: Total myectomy in the lower third of the esophagus caused gastroesophageal reflux in the majority of the animals.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License