Morphological and biomechanical study of abdominal aorta of rats submitted to experimental chronic alcoholism

Acta Cirurgica Brasileira

Nereide Freire Cerqueira²  Winston Bonetti Yoshida¹  Sérgio Swain Müller¹  Júlio Lopes Sequeira²  Antônio De Castro Rodrigues¹  Carlos Roberto Padovani¹ 

[1] ,UNESP School of Veterinary Medicine and Animal Science Botucatu

关键词: Alcoholism;    Ethanol;    Aorta;    Elasticity;    Alcoolismo;    Etanol;    Aorta;    Elasticidade;   

DOI  :  10.1590/S0102-86502005000300004

来源: SciELO

【 摘 要 】

PURPOSE: To assess the influence of experimental chronic alcoholism in the morphology and biomechanics of the aorta, in a rat model. METHODS: Forty-four Wistar rats were randomly divided into two groups of 22 animals each: in the alcoholism group, the rats received water mixed to increasing concentrations of ethyl alcohol; and control group: the rats received pure water for 180 days. The animals were then killed by an overdose of pentobarbital and the abdominal aortas were excised for histological (hematoxylin-eosin, Masson, Calleja, and Picrosirius red stain), histomorphometrical, and biomechanical analysis. RESULTS: Histology and histomorphometry did not show differences in aorta morphology of both groups. Biomechanical analysis showed a significantly greater yield point elongation in the alcoholic rat group (p<0.05). CONCLUSION: Chronic alcoholism did not cause morphological alterations in the aortic wall but increased elongation, without modifying any other mechanical properties.

【 授权许可】

CC BY   
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