Experimental model in hamster (Mesocricetus auratus) to study heterologous graft of scars and cutaneous diseases in plastic surgery

Acta Cirurgica Brasileira

Bernardo Hochman¹  Lydia Masako Ferreira¹  Flaviane Cássia Vilas Bôas¹  Mario Mariano¹ 

[1] ,UNIFESP EPM

关键词: Mesocricetus;    Transplantation;    heterologous;    Skin transplantation;    Keloid;    Mesocricetus;    Transplante heterólogo;    Transplante de pele;    Quelóide;   

DOI  :  10.1590/S0102-86502004000700013

来源: SciELO

【 摘 要 】

Syrian golden hamster (Mesocricetus auratus) has in its cheek pouches sub-epithelium an "Immunologically Privileged Site" which allows the integration of homo- and heterologous graft. This paper describes some anatomical and histological characteristics of that site, as well as analyzes aspects related with its immune properties. It also focuses the advantages of this experimental model over other models which are natural or induced carriers of immunodeficiency. Based on both these advantages and literature, this study aims to establish this model, through the performance of heterologous graft, as another option for the investigation of scar disturbances, as keloids and other diseases which may interest Plastic Surgery, as benign cutaneous lesions, and malignant neoplasias such as skin carcinomas and melanomas. The work also addresses perspectives for using this model, which still is a source scarcely known by Brazilian medical class.

【 授权许可】

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