Experimental model for graft -versus-host disease in rat limb allotransplantation

Acta Cirurgica Brasileira

Lydia Masako Ferreira¹ 

[1] ,UNIFESP Surgery Department Plastic Surgery Division

关键词: Graft versus host disease;    Limb transplantation;    Allotransplantation;    Microsurgery;    Method;    Sindrome Enxerto versus Hospedeiro;    Transplante alógeno;    Transplante de tecidos;    Microcirurgia;   

DOI  :  10.1590/S0102-86502004000700007

来源: SciELO

【 摘 要 】

Graft versus-host disease (GVHD) is a potentially fatal immune-regulated injury occurring unpredictably in solid organ and bone marrow transplant recipients. This model attempts the incidence of potentially lethal GVHD in limb transplants. Two inbred rat strains ACI and Lewis with a strong major and minor histocompatibility locus mismatch were studied. The perspectives of this model are study the incidence of GVHD in limb transplant, determine the best model for the study of the GVHD in limb transplant and prevention and treatment concerning the GVHD.

【 授权许可】

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