MicroRNAs and mesenchymal stem cells: hope for pulmonary hypertension

Revista Brasileira de Cirurgia Cardiovascular

Zhaowei Zhu¹  Zhenfei Fang¹  Xinqun Hu¹  Shenghua Zhou¹ 

关键词: Hypertension;    Pulmonary;    MicroRNAs;    Mesenchymal Stem Cell Transplantation;    Hipertensão Pulmonar;    MicroRNAs;    Transplante de Células-Tronco Mesenquimais;   

DOI  :  10.5935/1678-9741.20150033

来源: SciELO

【 摘 要 】

AbstractPulmonary hypertension is a devastating and refractory disease and there is no cure for this disease. Recently, microRNAs and mesenchymal stem cells emerged as novel methods to treat pulmonary hypertension. More than 20 kinds of microRNAs may participate in the process of pulmonary hypertension. It seems microRNAs or mesenchymal stem cells can ameliorate some symptoms of pulmonary hypertension in animals and even improve heart and lung function during pulmonary hypertension. Nevertheless, the relationship between mesenchymal stem cells, microRNAs and pulmonary hypertension is not clear. And the mechanisms underlying their function still need to be investigated. In this study we review the recent findings in mesenchymal stem cells - and microRNAs-based pulmonary hypertension treatment, focusing on the potential role of microRNAs regulated mesenchymal stem cells in pulmonary hypertension and the role of exosomes between mesenchymal stem cells and pulmonary hypertension.

【 授权许可】

CC BY   
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