Nebivolol in preventing atrial fibrillation following coronary surgery in patients over 60 years of age

Revista Brasileira de Cirurgia Cardiovascular

Nevzat Erdil¹  Murat Kaynak¹  Köksal Dönmez¹  Olcay Murat Disli¹  Bektas Battaloglu¹ 

关键词: Coronary Artery Bypass;    Atrial Fibrillation;    Anti-Arrhythmia Agents;    Drug Therapy;    Ponte de Artéria Coronária;    Fibrilação Atrial;    Antiarrítmicos;    Quimioterapia;   

DOI  :  10.5935/1678-9741.20140078

来源: SciELO

【 摘 要 】

Objective: Postoperative atrial fibrillation is a common complication after cardiac surgery, with an incidence as high as 20-50%. Increased age is associated with a significant increase in postoperative atrial fibrillation risk. This common complication is associated with higher morbidity and mortality rates. The aim of this study was to assess the efficacy of nebivolol in preventing atrial fibrillation following coronary artery bypass surgery in patients over 60 years of age. Methods: In this prospective randomized study, 200 patients who were candidates for elective coronary artery bypass surgery were divided into two groups. The first group was administered with nebivolol and the second group was administered with metoprolol. Treatment was initiated four days prior to surgery, and patients were monitored for atrial fibrillation until discharge. Forty-one patients recieved 50 mg metoprolol succinate daily, which was initiated minimum 4 days before surgery. Results: Demographic data were similar in both groups. The incidence of postoperative atrial fibrillation in both groups was similar, with no significant difference being identified [n=20 (20%); n=18 (18%), P=0.718; respectively]. There were not any mortality at both groups during study. Inotropic agent requirement at ICU was similar for both groups [n=12 (12%), n=18 (18%), P=0.32]. Conclusion: We compared the effectiveness of nebivolol and metoprolol in decreasing the incidence of postoperative atrial fibrillation, and determined that nebivolol was as effective as metoprolol in preventing postoperative atrial fibrillation at patients. Nebivolol may be the drug of choice due to its effects, especially after elective coronary artery bypass surgery.

【 授权许可】

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