Absence of arteriosclerosis in intramyocardial coronary arteries: a mystery to be solved?

Revista Brasileira de Cirurgia Cardiovascular

Edvaldo Luiz Ramalli Jr²  Leonardo Henrique Braga²  Patricia Martinez Evora¹  Agnes Afrodite Sumarelli Albuquerque¹  Andrea Carla Celotto¹  André Lupp Mota²  Paulo Roberto Barbosa Evora¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Surgery and Anatomy DepartmentRibeirão Preto SP ,Brazil

关键词: Myocardial bridging;    Coronary circulation;    Endothelium;    Ponte miocárdica;    Circulação coronária;    Endotélio;   

DOI  :  10.5935/1678-9741.20110020

来源: SciELO

【 摘 要 】

Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridges

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License