Musanga cecropioides leaf extract exhibits anti-inflammatory and anti-nociceptive activities in animal models

Revista Brasileira de Farmacognosia

Abimbola Sowemimo¹  Eboji Okwuchuku¹  Fageyinbo Muyiwa Samuel¹  Olowokudejo Ayoola¹  Ibrahim Mutiat¹ 

关键词: Musanga cecropioides;    Anti-inflammatory;    Anti-nociception;    Phenol;    Flavonoid;    Mineral content;   

DOI  :  10.1016/j.bjp.2015.07.022

来源: SciELO

【 摘 要 】

ABSTRACTExtract obtained from the leaves of Musanga cecropioides R. Br. ex Tedlie, Urticaceae, a tree growing in Africa, is used traditionally in the treatment of edema and rheumatism. The anti-inflammatory and anti-nociceptive properties of ethanol extract were studied using the carrageenan, histamine, serotonin and xylene-induced edema tests as well as the formalin, mouse writhing and tail clip tests. Significant dose dependent inhibition was observed in the carrageenan model with peak inhibition at 150 mg/kg (71.43%, 90 min, p < 0.001). In the histamine and serotonin models, the extract caused significant inhibition of 83.33% (p < 0.05) and 45% (p < 0.01) at 120 min respectively. For the xylene model, the extract showed maximum inhibition (59.25%) at 200 mg/kg. Also, M. cecropioides produced significant anti-nociceptive activity in the mouse writhing (55.12%, p < 0.01), formalin (81.88%, p < 0.01) and tail clip (11.78%, p< 0.001) tests at 200 mg/kg respectively. The results obtained in this study demonstrated that the ethanolic leaf extract of M. cecropioidespossesses anti-inflammatory effect possibly mediated via histaminergic and serotonergic inhibition and anti-nociceptive effect mediated via peripheral mechanism with mild central involvement.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License