Chemical composition, antischistosomal and cytotoxic effects of the essential oil of Lavandula angustifolia grown in Southeastern Brazil

Revista Brasileira de Farmacognosia

André L.l. Mantovani¹  Geovana P.g. Vieira¹  Wilson R. Cunha¹  Milton Groppo¹  Raquel A. Santos¹  Vanderlei Rodrigues¹  Lizandra G. Magalhães¹  Antônio E.m. Crotti¹ 

关键词: Schistosoma mansoni;    Essential oil;    Lavandula angustifolia;    Lavandula officinalis;   

DOI  :  10.1590/S0102-695X2013000600004

来源: SciELO

【 摘 要 】

This paper reports on the chemical composition, the in vitroantischistosomal effects, and the cytotoxicity of the essential oil from the leaves of Lavandula angustifolia Mill., Lamiaceae, grown in the Southeastern Brazil. Borneol (22.4%), epi-α-muurolol (13.4%), α-bisabolol (13.1%), precocene I (13.0%), and eucalyptol (7.9%) were the major essential oil constituents. Incubation with essential oil at 200 μg/ml killed all the adult S. mansoni worms after 24 h (LC50117.7 and 103.9 μg/ml at 24 and 120 h of incubation, respectively). At a concentration of 50 μg/ ml, the essential oil significantly decreased the motor activity and reduced the percentage of egg development after 120 h. In addition, the essential oil separated all the coupled S. mansoni worm pairs into individual male and female at 25 and 50 μg/ml within 120 and 24 h, respectively. This oil was cytotoxic to GM07492-A cells at only concentrations higher than 200 µg/ml (IC50243.7 µg/ml). These data indicate that LA-EO exhibits moderate in vitro activity against adult S. mansoniand exerts remarkable effects on eggs development.

【 授权许可】

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