Biologically active compounds from cyanobacteria extracts: in vivo and in vitro aspects

Revista Brasileira de Farmacognosia

Luciana R. Carvalho²  Adriana Costa-neves¹  Geanne A. A. Conserva²  Rafael L. Brunetti¹  Guilherme S. Hentschke²  Camila F. S. Malone²  Luce M. B. Torres²  Célia L. Sant'anna²  Marisa Rangel¹ 

[1] ,Instituto de Botânica Núcleo de Pesquisa em FicologiaSP ,Brazil

关键词: acetylcholinesterase activity;    Calothrix sp.;    Geitlerinema splendidum;    Phormidium cf. amoenum;    Phormidium sp.;    Tolypothrix sp;   

DOI  :  10.1590/S0102-695X2013005000037

来源: SciELO

【 摘 要 】

An investigation was directed towards the antiacetylcholinesterase activity of the acid aqueous and methanolic extracts of five cyanobacterial taxa, which encompasses an enzymatic inhibition essay and the evaluation of the physiological responses of mice to cyanobacterial extracts along with toxicological observations. The strains Calothrix sp. CCIBt 3320, Tolypothrix sp. CCIBt 3321, Phormidium cf. amoenum CCIBt 3412, Phormidium sp. CCIBt 3265, and Geitlerinema splendidum CCIBt 3223 were from the São Paulo Botanical Institute Cyanobacterial Culture Collection and all of them showed inhibitory effect on acetylcholinesterase activity (in vitro) and caused systemic effects similar to those described for anticholinesterase drugs (in vivo). With the exception of G. splendidum and Tolypothrix sp. strains, all extracts produced reversible antiacetylcolinesterase effects in mice. Complementary histopathological studies were carried out on tissues from animals administered with Phormidium sp. and P. cf. amoenum.

【 授权许可】

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