Assessment of mutagenic, antimutagenic and genotoxicity effects of Mimosa tenuiflora

Revista Brasileira de Farmacognosia

Viviane A. Silva²  Gregório F. Gonçalves²  Maria S. V. Pereira¹  Isis F. Gomes²  Andréa F. R. Freitas¹  Margareth F. F. M. Diniz²  Hilzeth L. F. Pessôa² 

[1] ,Universidade Federal da Paraíba Centro de Ciências da Saúde Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos,Brazil

关键词: Genetic toxicology;    medicinal plants;    Mimosa tenuiflora;    mutation;    natural products;   

DOI  :  10.1590/S0102-695X2013005000014

来源: SciELO

【 摘 要 】

Genotoxic effects of Mimosa tenuiflora (Willd.) Poir, Fabaceae, were investigated by using both micronucleus test and bacterial reverse mutation assay in Salmonella typhimurium TA97, TA98, TA100, TA102 respectively. In respect of Ames test results show that the extract does not induce mutations in any strains of Salmonella typhimurium tested since the mutagenicity index is less than 2. In the antimutagenic effect was observed that the extract at the concentrations tested significantly decreased the mutagenicity index of all strains tested which characterized the extract as antimutagenic in these conditions. In the micronucleus test in vivo, we observed that the concentrations used did not induce an increase in the frequency of micronucleus in normochromatic erythrocytes of mice. Therefore, we concluded that the extract of M. tenuiflora is not mutagenic in the absence of exogenous metabolizing system and does not induce an increase in the frequency of the micronucleus characterized as an agent not mutagenic in these conditions. Further studies of toxicity need to be made to the use of this plant in the treatment of diseases to be stimulated.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License