Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Revista Brasileira de Farmacognosia

Cínthia R. C. Porto²  Luiz A. L. Soares²  Tatiane P. Souza¹  Pedro R. Petrovick¹  Ibson L. Lyra¹  Raimundo F. Araújo Júnior¹  Silvana Maria Zucolotto Langassner¹  Aurigena A. A. Ferreira¹  Gerlane C. B. Guerra¹ 

[1] ,Universidade Federal do Rio Grande do Norte Programa de Pós-graduação em Ciências Farmacêuticas ,Brazil

关键词: antinociception;    anti-inflammation;    Phyllanthus niruri;    standardization;   

DOI  :  10.1590/S0102-695X2013005000004

来源: SciELO

【 摘 要 】

Phyllanthus niruri L., Euphorbiaceae, spray-dried standardized extract was studied for its anti-inflammatory and antinociceptive activities in adult albino rats and mice. The anti-inflammatory effect of spray-dried standardized extract was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects were observed using Randall & Selitto, tail flick, and hot plate tests. This study showed that intraperitoneal spray-dried standardized extract at 100, 200, 800, or 1600 mg/kg reduced the vascular response in the inflammatory process of paw edema induced by 1% carrageenan. Oral spray-dried standardized extract at 100 or 200 mg/kg inhibited leukocyte migration to the site of inflammation induced by 3% thioglycolate. In rats, at 100 and 200 mg/kg intraperitoneally, the extract exhibited a marked peripheral analgesic effect in a Randall & Selitto assay and showed significant central analgesic activity in a hot plate and tail flick assay. In conclusion, this study suggested that Phyllanthus niruri spray-dried standardized extract has potent inflammatory and antinociceptive activities and that these activities are not modified by standard drying process, making it feasible to use the dry extract standardized to obtain a phytotherapic preparation and thus validating its use for the treatment of pain and inflammation disorders.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License