Evaluation of wound healing activity of Acacia leucophloea bark in rats

Revista Brasileira de Farmacognosia

Sembian Suriyamoorthy¹  Kalidass Subramaniam¹  Femina Wahab¹  G Karthikeyan¹ 

[1] ,Karunya University School of Biotechnology and Health Sciences Department of Biotechnology Tamil Nadu ,India

关键词: Acacia leucophloea;    wound healing;    skin ointment;    biochemical;    histopathological;   

DOI  :  10.1590/S0102-695X2012005000121

来源: SciELO

【 摘 要 】

Wound healing activity of the bark extracts of Acacia leucophloea Willd., Fabaceae, was investigated by excision and incision wound healing models in Wistar male rats. Ethanolic extract based ointment of A. leucophloea bark (2 and 5% (w/w)) was formulated and evaluated for its wound healing in Wistar male rats. In comparision with a standard wound healing ointment betadine. A. leucophloea ethanolic extract ointment exhibited marked wound healing activity and significantly enhanced the wound contraction and the period of epithelialization as assessed by wound contraction rate, tensile strength, increasing of DNA, collagen and protein synthesis and histopathological examination. The formulated ointment might well find use as skin repair agent without hazard to human health based on these results.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License