Anti-ulcer activity of Synadenium grantii latex

Revista Brasileira de Farmacognosia

Larissa L. G. Costa¹  Vanessa C. David¹  Rodrigo M. C. Pinto¹  Bruno R. Minozzo¹  Vitoldo A. Kozlowski Junior¹  Letícia A. Campos¹  Rosi Z. Silva¹  Flávio L. Beltrame¹ 

[1] ,Universidade Estadual de Ponta Grossa,Brazil

关键词: Synadenium grantii;    latex;    toxicity;    gastric protection;   

DOI  :  10.1590/S0102-695X2012005000050

来源: SciELO

【 摘 要 】

Synadenium grantii Hook f., Euphorbiaceae, is popularly known as leitosinha or janaúba. The diluted latex (18 drops/L of water) is commonly used in the south of Brazil to treat gastric disturbances. This study evaluated phytochemical screening and toxicity using Artemia salina Leach of crude bark extract and also latex. The toxicity and the anti-ulcer activity of S. grantii latex were also tested in rats. Phytochemical results showed presence of tannins, terpenes, unsaponificable substances, coumarins and anthraquinones in the crude bark extract and terpenes in the latex. Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of diterpene tigliane esters in the latex, identified as 12-deoxyphorbol-13-(2-metilpropionate) and phorbol 12,13,20-triacetate. The toxicity results using A. salina presented CL50 26.58μg/mL and CL50 778.66μg/mL, for the latex and the crude bark extract respectively. The toxicological hepatic parameters of the diluted latex were not different to the control group (p<0.05). The eosinophils cells showed an increase in both the diluted and pure latex groups. The pure latex showed gastric protection of 90% (p<0.05) and the diluted latex showed 6% compared to the negative control. Therefore, our data indicate that S. grantii latex, under research conditions presented gastric protection. Pure latex showed more toxicity than the diluted latex.

【 授权许可】

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